• #LGM Pharma is a Famotidine CAS# 76824-35-6 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 76824-35-6
  • AHFC code: 56:28.1
  • Synonyms: Famotidina [Spanish] Famotidinum [Latin]
  • ATC Code: A02BA03
  • Chemical Formula: C15H17NO2
  • Molecular Weight: 337.445
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00927 (APRD00296)
  • SMILES: NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1
  • InChl: XUFQPHANEAPEMJ-UHFFFAOYSA-N
  • PubChem: 3325
  • IUPAC: 3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide

Additional Details

Indication:
For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD).
Pharmacodynamics:
Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Mode of Action:
Famotidine binds competitively to H_-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.
Metabolism:
Hepatic.
Toxicity:
Intravenous, mouse: LD50 = 244.4mg/kg; Oral, mouse: LD50 = 4686 mg/kg. Symptoms of overdose include emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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