• #LGM Pharma is a Etanercept CAS# 185243-69-0 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 185243-69-0
  • AHFC code: 32:00.0
  • Synonyms: CD120b p75 p80 TNF-alpha receptor TNF-R2 Tumor necrosis factor receptor 2 Tumor necrosis factor receptor superfamily member 1B precursor Tumor necrosis factor receptor type II
  • ATC Code: L04AB01
  • Chemical Formula: C18H19Cl2NO4
  • Molecular Weight: 51234.9
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00005 (BIOD00052, BTD00052)
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC:

Additional Details

Indication:
For treatment of severe active rheumatoid arthritis in adults, severe juvenile idiopathic arthritis, ankylosing spondylitis, and severe plaque psoriasis.
Pharmacodynamics:
Tumor necrosis factor TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. Elevated levels of TNF are found in tissues and fluids of patients with rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Etanercept binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors.
Mode of Action:
There are two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75). The biological activity of TNF is dependent upon binding to either cell surface receptor (p75 or p55). Etanercept is a dimeric soluble form of the p75 TNF receptor that can bind to two TNF molecules, thereby effectively removing them from circulation.
Metabolism:
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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