50-27-1 Category:
  • #LGM Pharma is a Estriol CAS# 50-27-1 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 50-27-1
  • AHFC code:
  • Synonyms: (16_,17_)-estra-1,3,5(10)-triene-3,16,17-triol 16-alpha-Hydroxyestradiol 16alpha-hydroxyestradiol 16_-hydroxyestradiol Oestriol
  • ATC Code: G03CC06 G03CA04
  • Chemical Formula: C11H14N2O4
  • Molecular Weight: 288.3814
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB04573 (DB05375, EXPT01361)
  • SMILES: C[C,]12CC[C,H]3[C,,H](CCC4=C3C=CC(O)=C4)[C,,H]1C[C,,H](O)[C,,H]2O
  • PubChem: 5756
  • IUPAC: (1S,10R,11S,13R,14R,15S)-15-methyltetracyclo[^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,13,14-triol

Additional Details

Used as a test to determine the general health of an unborn fetus.
Estriol (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.
Mode of Action:
Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a problem with the development of the child. The drug interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estriol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
ORAL (LD50): Acute: >2000 mg/kg [Rat].
General Reference:
Soldan SS, Alvarez Retuerto AI, Sicotte NL, Voskuhl RR: Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J Immunol. 2003 Dec 1;171(11):6267-74. Pubmed Trimesta
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