2998-57-4 Category:
  • #LGM Pharma is a Estramustine CAS# 2998-57-4 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 2998-57-4
  • AHFC code: 10:00.0
  • Synonyms: Estramustin Sodium Phosphate Estramustina [INN-Spanish] Estramustine Sodium Phosphate Estramustinum [INN-Latin]
  • ATC Code: L01XX11
  • Chemical Formula: C8H15N7O2S3
  • Molecular Weight: 440.403
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01196 (APRD00625)
  • SMILES: [H][C,,]12CC[C,H](O)[C,,]1(C)CC[C,]1([H])C3=CC=C(OC(=O)N(CCCl)CCCl)C=C3CC[C,,]21[H]
  • PubChem: 18140
  • IUPAC: (1S,10R,11S,14S,15S)-14-hydroxy-15-methyltetracyclo[^{2,7}.0^{11,15}]heptadeca-2(7),3,5-trien-5-yl N,N-bis(2-chloroethyl)carbamate

Additional Details

For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate
Estramustine is an antineoplastic agent indicated in the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate. Estramustine is a combination of estradiol with nitrogen mustard. In vivo, the nitrogen-mustard moiety becomes active and participates in alkylation of DNA or other cellular components.. This causes DNA damage in rapidly dividing cancerous cells leading to cell death and ideally, tumor shrinkage.
Mode of Action:
Estramustine is a derivative of estradiol with a nitrogen mustard moiety. This gives it alkylating properties. In vivo, the nitrogen mustard component is active and can alklyate DNA and other cellular components (such as tubulin components) of rapidly dividing cells. This causes DNA strandbreaks or misscoding events. This leads to apoptosis and cell death. Also, due to the drugs estrogen component, it can bind more selectively to active estrogen receptors.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Cost effective materials based on specific requirements
  • Small quantities for initial research and larger development quantities towards product commercialization


  • Technical packages, letters of access to filed DMFs
  • Complete assistance in any regulatory filings
  • Top quality GMP certified manufacturers
  • Have necessary regulatory credentials


Related YouTube Videos