Epothilone B

  • #LGM Pharma is a Epothilone B CAS# 152044-54-7 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 152044-54-7
  • AHFC code:
  • Synonyms: EPO 906, EPO906, patupilone
  • ATC Code:
  • Chemical Formula: C27H41NO6S
  • Molecular Weight: 507.683
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB03010 (EXPT01349)
  • SMILES: C[C,H]1CCC[C,]2(C)O[C,H]2C[C,H](OC(=O)C[C,,H](O)C(C)(C)C(=O)[C,,H](C)[C,,H]1O)C(C)=CC1=CSC(C)=N1
  • InChl: 1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17-,20-,21+,22-,24+,27-/m0/s1
  • PubChem:
  • IUPAC: (1S,3S,7R,10S,11R,12S,16S)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Additional Details

Indication:
Investigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer.Tubulin Modulator.
Pharmacodynamics:
Mode of Action:
The principal mechanism of the epothilone class is inhibition of microtubule function. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Epothilone B possess the same biological effects as taxol both in vitro and in cultured cells. This is because they share the same binding site, as well as binding affinity to the microtubule. Like taxol, epothilone B binds to the αβ-tubulin heterodimer subunit. Once bound, the rate of αβ-tubulin dissociation decreases, thus stabilizing the microtubules. Furthermore, epothilone B has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. This is caused by formation of microtubule bundles throughout the cytoplasm. Finally, epothilone B also causes cell cycle arrest at the G2-M transition phase, thus leading to cytotoxicity and eventually cell apoptosis.
Metabolism:
Toxicity:
General Reference:
PubChem Compound:http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=46936553PubChem Substance:http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505629Therapeutic Targets Database:http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DNC000616
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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