For the temporary relief of the signs and symptoms of allergic conjunctivitis.
Emedastine is a relatively selective H1-receptor antagonist.
Mode of Action:
Emedastine is a relatively selective, histamine H_ antagonist. In vitro examinations of emedastine's affinity for histamine receptors demonstrate relative selectivity for the H_ histamine receptor. In vivo studies have shown concentration-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva following topical ocular administration. Emedastine appears to be devoid of effects on adrenergic, dopaminergic and serotonin receptors.
Two primary metabolites, 5-hydroxyemedastine and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms. The 5'-oxoanalogs of 5-hydroxyemedastine and 6-hydroxy-emedastine and the N-oxide are also formed as minor metabolites.
Somnolence and malaise have been reported following daily oral administration.
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API’s From Quality Manufacturers:
Cost effective materials based on specific requirements
Small quantities for initial research and larger development quantities towards product commercialization
Technical packages, letters of access to filed DMFs