• #LGM Pharma is a Efalizumab CAS# 214745-43-4 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 214745-43-4
  • AHFC code: 84:92.00
  • Synonyms: anti-CD11a, Efalizumab, HSDB 7847, Hu 1124, hu1124, Immunoglobulin G 1 (human-mouse monoclonal hu1124 gamma1-chain anti-human antigen CD 11a), disulfide with human-mouse monoclonal hu1124 light chain, dimer. Molecular weight is approximately 146,170 daltons, Raptiva, UNII-XX2MN88N5D, Xanelim
  • ATC Code: L04AA21
  • Chemical Formula:
  • Molecular Weight:
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00095
  • SMILES:
  • InChl:
  • PubChem:
  • IUPAC: Immunoglobulin G1, anti-(human CD11a (antigen)) (human-mouse monoclonal hu1124 gamma1-chain), disulfide with human-mouse monoclonal hu1124 light chain, dimer

Additional Details

Indication:
For the treatment of adult patients with moderate to severe chronic plaque psoriasis, who are candidates for phototherapy or systemic therapy.
Pharmacodynamics:
Lymphocyte activation and trafficking to skin play a role in the pathophysiology of chronic plaque psoriasis. In psoriatic skin, ICAM-1 cell surface expression is upregulated on endothelium and keratinocytes. Raptiva inhibits the binding of LFA-1 to the intercellular adhesion molecule-1 (ICAM-1), thereby inhibiting the adhesion of leukocytes to other cell types.
Mode of Action:
Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. As a result efalizumab decreases cell surface expression of CD11a.
Metabolism:
Toxicity:
General Reference:
PubmedDescamps V: [Efalizumab] Ann Dermatol Venereol. 2006 Aug-Sep;133(8-9 Pt 1):666-78. Pubmed
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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