• #LGM Pharma is a Efalizumab CAS# 214745-43-4 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 214745-43-4
  • AHFC code: 84:92.00
  • Synonyms: anti-CD11a, Efalizumab, HSDB 7847, Hu 1124, hu1124, Immunoglobulin G 1 (human-mouse monoclonal hu1124 gamma1-chain anti-human antigen CD 11a), disulfide with human-mouse monoclonal hu1124 light chain, dimer. Molecular weight is approximately 146,170 daltons, Raptiva, UNII-XX2MN88N5D, Xanelim
  • ATC Code: L04AA21
  • Chemical Formula:
  • Molecular Weight:
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00095
  • InChl:
  • PubChem:
  • IUPAC: Immunoglobulin G1, anti-(human CD11a (antigen)) (human-mouse monoclonal hu1124 gamma1-chain), disulfide with human-mouse monoclonal hu1124 light chain, dimer

Additional Details

For the treatment of adult patients with moderate to severe chronic plaque psoriasis, who are candidates for phototherapy or systemic therapy.
Lymphocyte activation and trafficking to skin play a role in the pathophysiology of chronic plaque psoriasis. In psoriatic skin, ICAM-1 cell surface expression is upregulated on endothelium and keratinocytes. Raptiva inhibits the binding of LFA-1 to the intercellular adhesion molecule-1 (ICAM-1), thereby inhibiting the adhesion of leukocytes to other cell types.
Mode of Action:
Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes. As a result efalizumab decreases cell surface expression of CD11a.
General Reference:
PubmedDescamps V: [Efalizumab] Ann Dermatol Venereol. 2006 Aug-Sep;133(8-9 Pt 1):666-78. Pubmed
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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