152-62-5 Category:
  • #LGM Pharma is a Dydrogesterone CAS# 152-62-5 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 152-62-5
  • AHFC code:
  • Synonyms: 10alpha-Isopregnenone Didrogesterone [DCIT] Dydrogesterona [INN-Spanish] Dydrogesteronum [INN-Latin] Hydrogesterone Hydrogestrone Isopregnenone
  • ATC Code: G03DB01
  • Chemical Formula: C2224H3475N621O698S36
  • Molecular Weight: 312.4458
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00378 (APRD00941)
  • SMILES: CC(=O)[C,H]1CC[C,H]2[C,,H]3C=CC4=CC(=O)CC[C,,]4(C)[C,,H]3CC[C,]12C
  • PubChem: 9051
  • IUPAC: (1R,2S,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[^{2,7}.0^{11,15}]heptadeca-6,8-dien-5-one

Additional Details

Used to treat irregular duration of cycles and irregular occurrence and duration of periods caused by progesterone deficiency. Also used to prevent natural abortion in patients who have a history of habitual abortions.
Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol. Dydrogesterone helps to regulate the healthy growth and normal shedding of the uterus lining. Therefore, it may be useful in the treatment of menstrual disorders such as absent, irregular or painful menstrual periods, infertility, premenstrual syndrome and endometriosis.
Mode of Action:
Dydrogesterone is a progestogen that works by regulating the healthy growth and normal shedding of the womb lining by acting on progesterone receptors in the uterus.
Metabolism is complete to a 20-dihydrodydrogesterone (DHD) metabolite.
No serious or unexpected toxicity has been observed with dydrogesterone. In acute toxicity studies, the LD50 doses in rats exceeded 4,640mg/kg for the oral route.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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