Dronabinol

CAS No:
b1ef94b47b61 Category:
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Product Details:

  • CAS No:
  • AHFC code: 56:22.9
  • Synonyms:
  • ATC Code: A04AD10
  • Chemical Formula: C16H11ClN4
  • Molecular Weight: 314.4617
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00470 (APRD00571)
  • SMILES: CCCCCC1=CC(O)=C2[C,,H]3C=C(C)CC[C,H]3C(C)(C)OC2=C1
  • InChl: CYQFCXCEBYINGO-IAGOWNOFSA-N
  • PubChem:
  • IUPAC: (6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol

Additional Details

Indication:
For the treatment of anorexia associated with weight loss in patients with AIDS, and nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments
Pharmacodynamics:
Marinol may has complex effects on the central nervous system (CNS), including cannabinoid receptors. Dronabinol may inhibit endorphins in the emetic center, suppress prostaglandin synthesis, and/or inhibit medullary activity through an unspecified cortical action.
Mode of Action:
The mechanism of action of marinol is not completely understood. It is thought that cannabinoid receptors in neural tissues may mediate the effects of dronabinol and other cannabinoids. Animal studies with other cannabinoids suggest that marinol's antiemetic effects may be due to inhibition of the vomiting control mechanism in the medulla oblongata.
Metabolism:
Hepatic
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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