Dibucaine Hydrochloride

CAS No:
61-12-1 Categories: , ,
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Product Details:

  • CAS No: 61-12-1
  • AHFC code:
  • Synonyms: 2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide monohydrochloride, 2-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride, 2-Butoxy-N-(2-diethylaminoethyl)cinchoninic acid amide hydrochloride, 2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide hydrochloride, 4-Quinolinecarboxamide, 2-butoxy-N-(2-(diethylamino)ethyl)-, monohydrochloride, Benzolin (local anesthetic), Butoxycinchoninic acid diethylethylenediamide hydrochloride, C 3225, Cincaine chloride, Cincaine hydrochloride, Cinchocaine hydrochloride, Cinchocainium chloride, Cinchokain hydrochlorid, Cinchokain hydrochlorid [Czech], Dibucaine HCl, Dibucaine hydrochloride, EINECS 200-498-1, Heavy Solution Nupercaine, Nupercainal, Nupercaine, Nupercaine hydrochloride, Percain, Percaine, Percamin S, Sovcain, Sovcaine, Sovcainum, UNII-Z97702A5DG
  • ATC Code:
  • Chemical Formula: C20-H29-N3-O2.Cl-H
  • Molecular Weight: 379.929
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00527 (APRD00915)
  • SMILES: CCCCOc1cc(c2ccccc2n1)C(=O)NCCN(CC)CC.Cl
  • InChl: 1S/C20H29N3O2.ClH/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3;/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24);1H
  • PubChem:
  • IUPAC: 4-Quinolinecarboxamide, 2-butoxy-N-(2-(diethylamino)ethyl)-, monohydrochloride

Additional Details

Indication:
For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
Pharmacodynamics:
Dibucaine is an amide-type local anesthetic, similar to lidocaine.
Mode of Action:
Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel inhibition. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
Metabolism:
Primarily hepatic.
Toxicity:
Subcutaneous LD50 in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
General Reference:
Abdel-Ghani NT, Youssef AF, Awady MA: Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry. Farmaco. 2005 May;60(5):419-24. PubmedSouto-Padron T, Lima AP, Ribeiro Rde O: Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi. Parasitol Res. 2006 Sep;99(4):317-20. Epub 2006 Apr 13. PubmedNounou MM, El-Khordagui LK, Khalafallah N: Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles. Acta Pol Pharm. 2005 Sep-Oct;62(5):369-79. Pubmed
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