638-94-8 Category:
  • #LGM Pharma is a Desonide CAS# 638-94-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 638-94-8
  • AHFC code: 24:06.0
  • Synonyms:
  • ATC Code: D07AC09 R03BA02 S01BA11 A07EA06 D07AB08 R01AD05
  • Chemical Formula: C19H29NO5
  • Molecular Weight: 416.5073
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01260
  • SMILES: CC1(C)O[C,,H]2C[C,H]3[C,,H]4CCC5=CC(=O)C=C[C,]5(C)[C,H]4[C,,H](O)C[C,]3(C)[C,,]2(O1)C(=O)CO
  • PubChem: 12536
  • IUPAC: (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one

Additional Details

For the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatose.
Desonide is a synthetic nonfluorinated corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents.
Mode of Action:
Like other topical corticosteroids, desonide has anti-inflammatory, antipruritic and vasoconstrictive properties. The drug binds to cytosolic glucocorticoid receptors. This complex migrates to the nucleus and binds to genetic elements on the DNA. This activates and represses various genes. However corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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