Dapiprazole

CAS No:
72822-12-9 Categories: ,
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Product Details:

  • CAS No: 72822-12-9
  • AHFC code:
  • Synonyms:
  • ATC Code: S01EX02
  • Chemical Formula: C8H7ClN2O2S
  • Molecular Weight: 325.4512
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00298 (APRD00902)
  • SMILES: CC1=CC=CC=C1N1CCN(CCC2=NN=C3CCCCN23)CC1
  • InChl: RFWZESUMWJKKRN-UHFFFAOYSA-N
  • PubChem: 3033538
  • IUPAC: 1-(2-methylphenyl)-4-(2-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl}ethyl)piperazine

Additional Details

Indication:
Used in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents used in certain eye examinations.
Pharmacodynamics:
Dapiprazole is an alpha-adrenergic blocking agent. It produces miosis by blocking the alpha-adrenergic receptors on the dilator muscle of the iris. Dapiprazole produces no significant action on ciliary muscle contraction and thus, there are no changes in the depth of the anterior chamber of the thickness of the lens. It does not alter the IOP either in normal eyes or in eyes with elevated IOP. The rate of pupillary constriction may be slightly slower in clients with brown irises than in clients with blue or green irises.
Mode of Action:
Dapiprazole acts through blocking the alpha1-adrenergic receptors in smooth muscle. It produces miosis through an effect on the dilator muscle of the iris and does not have any significant activity on ciliary muscle contraction and, therefore does not induce a significant change in the anterior chamber depth or the thickness of the lens.
Metabolism:
Toxicity:
Oral LD50 is 1189-2100 mg/kg in mice, rats and rabbits.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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