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Product Details:

  • CAS No: 152923-56-3
  • AHFC code: 32:00.0
  • Synonyms: Dacliximab Daclizumab Humanized anti-TAC monoclonal antibody comprised of four subunits, two heavy chains and two light chains. All four chains are linked via disulfide bridges. The molecule contains approximately 2% carbohydrate by weight. The antibody belongs to the IgG1 subclass. The DNA sequence is 90% human origin and 10% mouse origin. The humanized anti-TAC is directed to the TAC receptor or high-affinity interleukin 2 receptor. Immunoglobulin G 1 (human-mouse monoclonal clone 1H4 gamma-chain anti-human interleukin 2 receptor), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer. Molecular weight is approximately 150,000 daltons Immunoglobulin G 1 (human-mouse monoclonal clone 1H4 gamma-chain anti-human interleukin 2 receptor), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer Ro 24-7375 UNII-CUJ2MVI71Y Zenapax Anti-IL-2 Humanized antiCD25 Ig gamma-1 chain C region
  • ATC Code: L04AC01
  • Chemical Formula: C24H32O6
  • Molecular Weight: 142612.1
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00111 (BIOD00007, BTD00007)
  • SMILES:
  • InChl:
  • PubChem: BTD00007
  • IUPAC: Immunoglobulin G 1 (human-mouse monoclonal clone 1H4 gamma-chain anti-human interleukin 2 receptor), disulfide with human-mouse monoclonal clone 1H4 light chain, dimer

Additional Details

Indication:
Zenapax is a humanized monoclonal antibody used for prevention of renal transplant rejection
Pharmacodynamics:
Zenapax functions as an IL-2 receptor antagonist. Specifically it inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection.
Mode of Action:
Zenepax binds with high-affinity to the Tac subunit of the high-affinity IL-2 receptor complex and inhibits IL-2 binding. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes.
Metabolism:
Most likely removed by opsonization via the reticuloendothelial system when bound to lymphocytes.
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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