Dacarbazine

CAS No:
c18dd4c179a6 Category:
  • #LGM Pharma is a Dacarbazine CAS# API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No:
  • AHFC code: 10:00.0
  • Synonyms: Biocarbazine R Dacarbazino [INN-Spanish] Dacarbazinum [INN-Latin] DTIC Dtic-Dome DTIE ICDMT ICDT Imidazole Carboxamide
  • ATC Code: L01AX04
  • Chemical Formula: C18H22N2
  • Molecular Weight: 182.1832
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00851 (APRD00331)
  • SMILES: CN(C)N=NC1=C(N=CN1)C(N)=O
  • InChl: FDKXTQMXEQVLRF-UHFFFAOYSA-N
  • PubChem: 2942
  • IUPAC: 5-(dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide

Additional Details

Indication:
For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents.
Pharmacodynamics:
Dacarbazine is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). After intravenous administration of dacarbazine, the volume of distribution exceeds total body water content suggesting localization in some body tissue, probably the liver. Its disappearance from the plasma is biphasic with initial half-life of 19 minutes and a terminal half-life of 5 hours. 1 In a patient with renal and hepatic dysfunctions, the half-lives were lengthened to 55 minutes and 7.2 hours. 1 The average cumulative excretion of unchanged DTIC in the urine is 40% of the injected dose in 6 hours. 1 DTIC is subject to renal tubular secretion rather than glomerular filtration. At therapeutic concentrations dacarbazine is not appreciably bound to human plasma protein.
Mode of Action:
The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by its action as a purine analog, and interaction with SH groups. Dacarbazine is not cell cycle-phase specific.
Metabolism:
Hepatic
Toxicity:
LD50=350mg/kg (orally in mice)
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Cost effective materials based on specific requirements
  • Small quantities for initial research and larger development quantities towards product commercialization

 

  • Technical packages, letters of access to filed DMFs
  • Complete assistance in any regulatory filings
  • Top quality GMP certified manufacturers
  • Have necessary regulatory credentials

 

Related YouTube Videos