• #LGM Pharma is a Cilazapril CAS# 92077-78-6 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 92077-78-6
  • AHFC code: 24:32.0
  • Synonyms: Inhibace
  • ATC Code: C09AA08
  • Chemical Formula: C12H15ClO3
  • Molecular Weight: 417.4986
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01340
  • SMILES: CCOC(=O)[C,H](CCC1=CC=CC=C1)N[C,H]1CCCN2CCC[C,H](N2C1=O)C(O)=O
  • InChl: HHHKFGXWKKUNCY-FHWLQOOXSA-N
  • PubChem: 56330
  • IUPAC: (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

Additional Details

Indication:
Cilazapril is an ACE inhibtor class drug used in the treatment of hypertension and heart failure.
Pharmacodynamics:
Cilazapril inhibits the production angiotensin II. By doing so, it decreases sodium and water reabsorption (via aldosterone) and it decreases vasoconstriction. The combined effect of this is a decrease in vascular resistance, and therefore, blood pressure.
Mode of Action:
Cilazapril is a pyridazine ACE inhibitor. It competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. As angiotensin II is a vasoconstrictor and a negative feedback mediator for renin activity, lower angiotensin II levels results in a decrease in blood pressure, an increase in renin activity, and stimulation of baroreceptor reflex mechanisms. Kininase II, an enzyme which degrades the vasodilator bradykinin, is identical to ACE and may also be inhibited.
Metabolism:
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Cost effective materials based on specific requirements
  • Small quantities for initial research and larger development quantities towards product commercialization

 

  • Technical packages, letters of access to filed DMFs
  • Complete assistance in any regulatory filings
  • Top quality GMP certified manufacturers
  • Have necessary regulatory credentials

 

Related YouTube Videos