Chlorpropamide

CAS No:
94-20-2 Categories: , ,
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Product Details:

  • CAS No: 94-20-2
  • AHFC code: 08:20.2
  • Synonyms: Chlorporpamide
  • ATC Code: A10BB02
  • Chemical Formula: C10H12ClN5O3
  • Molecular Weight: 276.74
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00672 (APRD00029)
  • SMILES: CCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1
  • InChl: RKWGIWYCVPQPMF-UHFFFAOYSA-N
  • PubChem: 2727
  • IUPAC: 1-[(4-chlorobenzene)sulfonyl]-3-propylurea

Additional Details

Indication:
For treatment of NIDDM in conjunction with diet and exercise.
Pharmacodynamics:
Chlorpropamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Chlorpropamide is twice as potent as the related second-generation agent glipizide.
Mode of Action:
Sulfonylureas such as chlorpropamide bind to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
Metabolism:
Up to 80% of dose is metabolized likely through the liver to to 2-hydroxylchlorpropamide (2-OH CPA), p-chlorobenzenesulfonylurea (CBSU), 3-hydroxylchlorpropamide (3-OH CPA), and p-chlorobenzenesulfonamide (CBSA); CBSA may be produced by decomposition in urine. It is unknown whether chlorpropamide metabolites exert hypoglycemic effects.
Toxicity:
IPN-RAT LD50 580 mg/kg
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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