Chlorhexidine Acetate

  • #LGM Pharma is a Chlorhexidine Acetate CAS# 56-95-1 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 56-95-1
  • AHFC code: 34:00.00, 52:04.92, 84:04.92
  • Synonyms: 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) diacetate, 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) diacetate, 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide)diacetate, 1,6-Bis(5-(p-chlorophenyl)biguandino)hexane diacetate, 1,6-Bis(p-chlorophenylbiguanido)hexane diacetate, 1,6-Di(4'-chlorophenyldiguanidino)hexane diacetate, 10,040 Diacetate, Bactigras, Bis(p-chlorophenyldiguanidohexane) diacetate, Caswell No. 481E, Chlorhexidine acetate, Chlorhexidine acetate (VAN), Chlorhexidine diacetate, Chlorohexidine diacetate, EINECS 200-302-4, EPA Pesticide Chemical Code 045502, Hibitane diacetate, Nolvasan, NSC 526936, UNII-5908ZUF22Y
  • ATC Code: A01AB03" B05CA02" D08AC02" D09AA12" R02AA05" S01AX09" S02AA09" S03AA04
  • Chemical Formula: C22-H30-Cl2-N10.2C2-H4-O2
  • Molecular Weight: 625.5582
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00878 (APRD00545)
  • SMILES: CC(=O)O.CC(=O)O.c1cc(ccc1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(cc2)Cl)Cl
  • InChl: 1S/C22H30Cl2N10.2C2H4O2/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18;2*1-2(3)4/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34);2*1H3,(H,3,4)
  • PubChem:
  • IUPAC:

Additional Details

For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures. Also for prevention of dental caries, oropharyngeal decontamination in critically ill patients, hand hygiene in health-care personnel, general skin cleanser, and catheter site preparation and care.
Chlorhexidine, a topical antimicrobial agent, is bactericidal. Because of its positive charge, the chlorhexidine molecule reacts with the microbial cell surface to destroy the integrity of the cell membrane. This novel mechanism of action makes it highly unlikely for the development of bacterial resistance.
Mode of Action:
Chlorhexidine's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.
LD50= 2g/kg (human, oral); LD50= 3 g/kg (rat, oral); LD50= 2.5 g/kg (mice, oral); LD50= 21 mg/kg (male rat, IV); LD50= 23 mg/kg (female rat, IV); LD50= 25 mg/kg (male mice, IV); LD50= 24 mg/kg (female mice, IV); LD50= 1g/kg (rat, subcutaneous); LD50= 637 mg/kg (male mice, subcutaneous); LD50= 632 mg/kg (female mice, subcutaneous)
General Reference:
McBain AJ, Bartolo RG, Catrenich CE, Charbonneau D, Ledder RG, Gilbert P: Effects of a chlorhexidine gluconate-containing mouthwash on the vitality and antimicrobial susceptibility of in vitro oral bacterial ecosystems. Appl Environ Microbiol. 2003 Aug;69(8):4770-6. Pubmed
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