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Product Details:

  • CAS No: 130143-01-0
  • AHFC code: 32:00.0
  • Synonyms: Cetrorelix acetate, Cetrotide, D 20761, D-20761, D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N(sup 5)-(aminocarbonyl)-D-ornithyl-L-leucyl-L-argyinyl-L-prolyl-, acetate (salt), N-Acetyl-3-(2-naphthyl)-D-alanyl-p-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-L-tyrosyl-N(sup 5)-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide acetate (salt), NS 75a, NS-75A, SB 075 acetate, SB-075 acetate, UNII-W9Y8L7GP4C
  • ATC Code: H01CC02
  • Chemical Formula: C70-H92-Cl-N17-O14.x-C2-H4-O2
  • Molecular Weight: 1491.1064
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00050 (APRD00686, BIOD00115, BTD00115)
  • SMILES: C[C,H](C(=O)N)NC(=O)[C,,H]1CCCN1C(=O)[C,H](CCCNC(=N)N)NC(=O)[C,H](CC(C)C)NC(=O)[C,,H](CCCNC(=O)N)NC(=O)[C,,H](Cc2ccc(cc2)O)NC(=O)[C,,H](CO)NC(=O)[C,,H](Cc3cccnc3)NC(=O)[C,H](Cc4ccc(cc4)Cl)NC(=O)[C,,H](Cc5ccc6ccccc6c5)NC(=O)C.CC(=O)O
  • InChl:
  • PubChem:
  • IUPAC: D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-, acetate (salt)

Additional Details

For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation
Cetrorelix is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently luteinization as indicated by rising progesterone levels. Cetrorelix competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.
Mode of Action:
Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.
In in vitro studies, cetrorelix was stable against phase I- and phase II-metabolism. Cetrorelix was transformed by peptidases, and the (1-4) peptide was the predominant metabolite.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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