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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 92665-29-7
  • AHFC code: 08:12.06.08
  • Synonyms: Cefprozil anhydrous Cefprozilo [INN-Spanish] Cefprozilum [INN-Latin]
  • ATC Code: J01DC10
  • Chemical Formula: C26H28N2
  • Molecular Weight: 389.426
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01150 (APRD00461)
  • SMILES: [H][C,]12SCC(C=CC)=C(N1C(=O)[C,,]2([H])NC(=O)[C,H](N)C1=CC=C(O)C=C1)C(O)=O
  • InChl: WDLWHQDACQUCJR-ZAMMOSSLSA-N
  • PubChem: 9887643
  • IUPAC: (6R,7R)-7-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Additional Details

Indication:
For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Pharmacodynamics:
Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections.
Mode of Action:
Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.
Metabolism:
Cefprozil is eliminated primarily by the kidneys
Toxicity:
Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weaning or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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