Cefoxitin

CAS No:
35607-66-0 Categories: , ,
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Product Details:

  • CAS No: 35607-66-0
  • AHFC code: 08:12.07.12
  • Synonyms:
  • ATC Code: J01DC01
  • Chemical Formula: C21H30N4O4
  • Molecular Weight: 427.452
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01331 (EXPT00897)
  • SMILES: CO[C,]1(NC(=O)CC2=CC=CS2)[C,H]2SCC(COC(N)=O)=C(N2C1=O)C(O)=O
  • InChl: WZOZEZRFJCJXNZ-ZBFHGGJFSA-N
  • PubChem: 441199
  • IUPAC: (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Additional Details

Indication:
For the treatment of serious infections caused by susceptible strains microorganisms.
Pharmacodynamics:
Cefoxitin is a cephamycin antibiotic often grouped with the second-generation cephalosporins. It is active against a broad range of gram-negative bacteria including anaerobes. The methoxy group in the 7a position provides cefoxitin with a high degree of stability in the presence of beta-lactamases, both penicillinases and cephalosporinases, of gram-negative bacteria.
Mode of Action:
The bactericidal action of cefoxitin results from inhibition of cell wall synthesis.
Metabolism:
Minimal (approximately 85 percent of cefoxitin is excreted unchanged by the kidneys over a 6-hour period).
Toxicity:
The acute intravenous LD50 in the adult female mouse and rabbit was about 8.0 g/kg and greater than 1.0 g/kg, respectively. The acute intraperitoneal LD50 in the adult rat was greater than 10.0 g/kg.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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