• #LGM Pharma is a Carmustine CAS# 154-93-8 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 154-93-8
  • AHFC code: 10:00.0
  • Synonyms: BCNU Bischlorethylnitrosourea Bischlorethylnitrosurea Carmustin
  • ATC Code: L01AD01
  • Chemical Formula: C12H17NO2
  • Molecular Weight: 214.05
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00262 (APRD00006)
  • SMILES: ClCCNC(=O)N(CCCl)N=O
  • InChl: DLGOEMSEDOSKAD-UHFFFAOYSA-N
  • PubChem: 2578
  • IUPAC: 1,3-bis(2-chloroethyl)-1-nitrosourea

Additional Details

Indication:
For the treatment of brain tumors, multiple myeloma, Hodgkin’s disease and Non-Hodgkin’s lymphomas.
Pharmacodynamics:
Carmustine is one of the nitrosoureas indicated as palliative therapy as a single agent or in established combination therapy with other approved chemotherapeutic agents in treatment of brain tumors, multiple myeloma, Hodgkin’s disease, and non-Hodgkin’s lymphomas. Although it is generally agreed that carmustine alkylates DNA and RNA, it is not cross resistant with other alkylators. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins.
Mode of Action:
Carmustine causes cross-links in DNA and RNA, leading to the inhibition of DNA synthesis, RNA production and RNA translation (protein synthesis). Carmustine also binds to and modifies (carbamoylates) glutathione reductase. This leads to cell death.
Metabolism:
Hepatic and rapid with active metabolites. Metabolites may persist in the plasma for several days.
Toxicity:
The oral LD50s in rat and mouse are 20 mg/kg and 45 mg/kg, respectively. Side effects include leukopenia, thrombocytopenia, nausea. Toxic effects include pulmonary fibrosis (20-0%) and bone marrow toxicity.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

API’s From Quality Manufacturers:

  • Cost effective materials based on specific requirements
  • Small quantities for initial research and larger development quantities towards product commercialization

 

  • Technical packages, letters of access to filed DMFs
  • Complete assistance in any regulatory filings
  • Top quality GMP certified manufacturers
  • Have necessary regulatory credentials

 

Related YouTube Videos