Carbamazepine

CAS No:
298-46-4 Category:
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Product Details:

  • CAS No: 298-46-4
  • AHFC code: 28:12.9
  • Synonyms: Carbamezepine
  • ATC Code: N03AF01
  • Chemical Formula: C70H92ClN17O14
  • Molecular Weight: 236.2686
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00564 (APRD00337)
  • SMILES: NC(=O)N1C2=CC=CC=C2C=CC2=CC=CC=C12
  • InChl: FFGPTBGBLSHEPO-UHFFFAOYSA-N
  • PubChem: 2554
  • IUPAC: 2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene-2-carboxamide

Additional Details

Indication:
For the treatment of epilepsy and pain associated with true trigeminal neuralgia.
Pharmacodynamics:
Carbamazepine, an anticonvulsant structurally similar to tricyclic antidepressants, is used to treat partial seizures, tonic-clonic seizures, pain of neurologic origin such as trigeminal neuralgia, and psychiatric disorders including manic-depressive illness and aggression due to dementia.
Mode of Action:
Carbamazepine inhibits sustained repetitive firing by blocking use-dependent sodium channels. Pain relief is believed to be associated with blockade of synaptic transmission in the trigeminal nucleus and seizure control with reduction of post-tetanic potentiation of synaptic transmission in the spinal cord. Carbamazepine also possesses anticholinergic, central antidiuretic, antiarrhythmic, muscle relaxant, antidepressant (possibly through blockade of norepinephrine release), sedative, and neuromuscular-blocking properties.
Metabolism:
Hepatic
Toxicity:
Mild ingestions cause vomiting, drowsiness, ataxia, slurred speech, nystagmus, dystonic reactions, and hallucinations. Severe intoxications may produce coma, seizures, respiratory depression, and hypotension
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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