Calcipotriol

  • #LGM Pharma is a Calcipotriol CAS# 112965-21-6 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 112965-21-6
  • AHFC code:
  • Synonyms: Calcipotriene
  • ATC Code: D05AX02
  • Chemical Formula: C18H19N3O5S
  • Molecular Weight: 412.6047
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB02300 (EXPT02131)
  • SMILES: O[C,H](C=C[C,,H](C)[C,,]1([H])CC[C,,]2([H])C(CCC[C,]12C)=CC=C1C[C,,H](O)C[C,H](O)C1=C)C1CC1
  • InChl: LWQQLNNNIPYSNX-UROSTWAQSA-N
  • PubChem: 5288783
  • IUPAC: (1R,3S,5Z)-5-{2-[(1R,3aS,4E,7aR)-1-[(2R,3E,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol

Additional Details

Indication:
For the treatment of moderate plaque psoriasis in adults.
Pharmacodynamics:
Calcipotriene is a synthetic analog of vitamin D. In humans, the natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol to vitamin D3 (cholecalciferol) in the skin.
Mode of Action:
The precise mechanism of calcipotriol in remitting psoriasis is not well-understood. However, it has been shown to have comparable affinity with calcitriol for the Vitamin D receptor, while being less than 1% as active as the calcitriol in regulating calcium metabolism. The Vitamin D receptor (VDR) belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. T cells are known to play a role in psoriasis, and it is thought that the binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation related genes.
Metabolism:
Hepatic. Calcipotriene metabolism following systemic uptake is rapid, and occurs via a similar pathway to the natural hormone. The primary metabolites are much less potent than the parent compound.
Toxicity:
Topically applied calcipotriene can be absorbed in sufficient amounts to produce systemic effects. Elevated serum calcium has been observed with excessive use of calcipotriene.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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