Brimonidine

CAS No:
59803-98-4 Categories: , ,
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Product Details:

  • CAS No: 59803-98-4
  • AHFC code: 53:32.0
  • Synonyms: Brimonidine tartrate Bromoxidine
  • ATC Code: S01EA05
  • Chemical Formula: C9H15NO3S
  • Molecular Weight: 292.135
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00484 (APRD00034)
  • SMILES: BrC1=C(NC2=NCCN2)C=CC2=NC=CN=C12
  • InChl: XYLJNLCSTIOKRM-UHFFFAOYSA-N
  • PubChem: 2435
  • IUPAC: 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine

Additional Details

Indication:
For the lowering of intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Pharmacodynamics:
Brimonidine significantly lowers intraocular pressure with minimal effects on cardiovascular and pulmonary parameters. It lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow.
Mode of Action:
Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2). It has a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that Brimonidine has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.
Metabolism:
Metabolized primarily by the liver.
Toxicity:
Oral LD50 is 50 mg/kg in mice and 100 mg/kg in rats.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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