Bevantolol

CAS No:
59170-23-9 Category:
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Product Details:

  • CAS No: 59170-23-9
  • AHFC code:
  • Synonyms: 1-(3,4-Dimethoxyphenethylamino)-3-(m-tolyloxy)-2-propanol Bevantololum [inn-latin]
  • ATC Code: C07AB06
  • Chemical Formula: C18H28N2O
  • Molecular Weight: 345.4327
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01295
  • SMILES: COC1=C(OC)C=C(CCNCC(O)COC2=CC=CC(C)=C2)C=C1
  • InChl: HXLAFSUPPDYFEO-UHFFFAOYSA-N
  • PubChem: 2372
  • IUPAC: [2-(3,4-dimethoxyphenyl)ethyl][2-hydroxy-3-(3-methylphenoxy)propyl]amine

Additional Details

Indication:
For the treatment of angina pectoris and hypertension.
Pharmacodynamics:
Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension.
Mode of Action:
Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors. By binding and antagonizing beta-1 receptors Bevantolol inhibits the normal normal epinephrine-mediated sympathetic actions such as increased heart rate. This has the effect of decreasing preload and blood pressure.
Metabolism:
Toxicity:
General Reference:
Vaughan Williams EM: Bevantolol: a beta-1 adrenoceptor antagonist with unique additional actions. J Clin Pharmacol. 1987 Jul;27(7):450-60. Pubmed
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