Benzocaine

CAS No:
94-09-7 Category:
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Product Details:

  • CAS No: 94-09-7
  • AHFC code: 52:16.00 84:08.00
  • Synonyms: Ethyl Aminobenzoate Ethyl P-Aminobenzoate Ethyl P-Aminophenylcarboxylate Ethylester Kyseliny P-Aminobenzoove P-Aminobenzoic Acid, Ethyl Ester P-Carbethoxyaniline P-Ethoxycarboxylic Aniline
  • ATC Code: C05AD03 D04AB04 N01BA05 R02AD01 A01AD11
  • Chemical Formula: C23H28N2O3
  • Molecular Weight: 165.1891
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01086 (APRD00539)
  • SMILES: CCOC(=O)C1=CC=C(N)C=C1
  • InChl: BLFLLBZGZJTVJG-UHFFFAOYSA-N
  • PubChem: 2337
  • IUPAC: ethyl 4-aminobenzoate

Additional Details

Indication:
For general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex.
Pharmacodynamics:
Benzocaine is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter analgesic ointments. It is also indicated for general use as a lubricant and topical anesthetic on intratracheal catheters and pharyngeal and nasal airways to obtund the pharyngeal and tracheal reflexes; on nasogastric and endoscopic tubes; urinary catheters; laryngoscopes; proctoscopes; sigmoidoscopes and vaginal specula.
Mode of Action:
Benzocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
Metabolism:
Toxicity:
LD50=3040 mg/kg (rat, oral)
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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