• #LGM Pharma is a Azithromycin CAS# 83905-01-5 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 83905-01-5
  • AHFC code: 08:12.12.92
  • Synonyms: Azithramycine Azithromycin Dihydrate Azithromycine [French] Azithromycinum [Latin] Azitromicina [Spanish]
  • ATC Code: J01FA10 S01AA26
  • Chemical Formula: C22H18N2
  • Molecular Weight: 748.9845
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00207 (APRD00397)
  • SMILES: CC[C,H]1OC(=O)[C,H](C)[C,,H](O[C,H]2C[C,,](C)(OC)[C,,H](O)[C,H](C)O2)[C,H](C)[C,,H](O[C,,H]2O[C,H](C)C[C,,H]([C,H]2O)N(C)C)[C,](C)(O)C[C,,H](C)CN(C)[C,H](C)[C,,H](O)[C,]1(C)O
  • InChl: MQTOSJVFKKJCRP-BICOPXKESA-N
  • PubChem: 55185
  • IUPAC:

Additional Details

Indication:
For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: H. influenzae, M. catarrhalis, S. pneumoniae, C. pneumoniae, M. pneumoniae, S. pyogenes, S. aureus, S. agal
Pharmacodynamics:
Azithromycin, a semisynthetic antibiotic belonging to the macrolide subgroup of azalides, is used to treat STDs due to chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex (MAC) in patients with advanced HIV disease. Similar in structure to erythromycin. azithromycin reaches higher intracellular concentrations than erythromycin, increasing its efficacy and duration of action.
Mode of Action:
Azithromycin binds to the 50S subunit of the 70S bacterial ribosomes, and therefore inhibits RNA-dependent protein synthesis in bacterial cells.
Metabolism:
Hepatic. In vitro and in vivo studies to assess the metabolism of azithromycin have not been performed.
Toxicity:
Potentially serious side effects of angioedema and cholestatic jaundice were reported
General Reference:
Noedl H, Krudsood S, Chalermratana K, Silachamroon U, Leowattana W, Tangpukdee N, Looareesuwan S, Miller RS, Fukuda M, Jongsakul K, Sriwichai S, Rowan J, Bhattacharyya H, Ohrt C, Knirsch C: Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in Thailand. Clin Infect Dis. 2006 Nov 15;43(10):1264-71. Epub 2006 Oct 12. Pubmed
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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