Antazoline phosphate

CAS No:
154-68-7 Category:
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Product Details:

  • CAS No: 154-68-7
  • AHFC code:
  • Synonyms: Phenazolin Phenazoline
  • ATC Code: R01AC04
  • Chemical Formula: C9H11NO2
  • Molecular Weight: 265.3529
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB08799
  • SMILES: C(N(CC1=CC=CC=C1)C1=CC=CC=C1)C1=NCCN1
  • InChl: REYFJDPCWQRWAA-UHFFFAOYSA-N
  • PubChem: 2200
  • IUPAC: N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline

Additional Details

Indication:
Used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.
Pharmacodynamics:
Antazoline is a histamine H1 receptor antagonist. It selectively bind to but does not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
Mode of Action:
Antazoline binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Metabolism:
Toxicity:
General Reference:
Figus M, Fogagnolo P, Lazzeri S, Capizzi F, Romagnoli M, Canovetti A, Iester M, Ferreras A, Rossetti L, Nardi M: Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study. Eur J Ophthalmol. 2010 Sep-Oct;20(5):811-8. Pubmed
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