Amsacrine

  • #LGM Pharma is a Amsacrine CAS# 51264-14-3 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 51264-14-3
  • AHFC code: 10:00.0
  • Synonyms: Acridinyl Anisidide M-AMSA MAMSA
  • ATC Code: L01XX01
  • Chemical Formula: C10H12ClNO2
  • Molecular Weight: 393.459
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00276 (APRD00064)
  • SMILES: COC1=C(NC2=C3C=CC=CC3=NC3=CC=CC=C23)C=CC(NS(C)(=O)=O)=C1
  • InChl: XCPGHVQEEXUHNC-UHFFFAOYSA-N
  • PubChem: 2179
  • IUPAC: N-{4-[(acridin-9-yl)amino]-3-methoxyphenyl}methanesulfonamide

Additional Details

Indication:
For treatment of acute myeloid leukaemia.
Pharmacodynamics:
Amsacrine is an aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.
Mode of Action:
Amsacrine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. Amsacrine appears to cleave DNA by inducing double stranded breaks. Amsacrine also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum.
Metabolism:
Extensive, primarily hepatic, converted to glutathione conjugate.
Toxicity:
Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely).
General Reference:
Link
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