Amphotericin B

  • #LGM Pharma is a Amphotericin B CAS# 1397-89-3 API supplier distributor based in the USA. Inquire about DMF, cGMP, price, availability, delivery, purity, and more.
  • #Questions? Call our customer API support number 1-(800)-881-8210.
  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 1397-89-3
  • AHFC code: 08:14.3
  • Synonyms: AMPH-B Amphortericin B Amphotericine B Liposomal Amphotericin B
  • ATC Code: A01AB04 A07AA07 G01AA03 J02AA01
  • Chemical Formula: C38H72N2O12
  • Molecular Weight: 924.079
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00681 (APRD00797)
  • SMILES: C[C,H]1O[C,,H](O[C,,H]2C[C,,H]3O[C,,](O)(C[C,H](O)[C,H]3C(O)=O)C[C,,H](O)C[C,,H](O)[C,H](O)CC[C,,H](O)C[C,,H](O)CC(=O)O[C,,H](C)[C,H](C)[C,H](O)[C,,H](C)C=CC=CC=CC=CC=CC=CC=C2)[C,,H](O)[C,,H](N)[C,,H]1O
  • InChl: APKFDSVGJQXUKY-INPOYWNPSA-N
  • PubChem: 14956
  • IUPAC:

Additional Details

Indication:
Used to treat potentially life threatening fungal infections.
Pharmacodynamics:
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Mode of Action:
Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols (ergosterol) in the cell membrane of susceptible fungi. This creates a transmembrane channel, and the resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Amphotericin B, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
Metabolism:
Exclusively renal
Toxicity:
Oral, rat: LD50 = >5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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