Amlexanox

CAS No:
68302-57-8 Category:
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Product Details:

  • CAS No: 68302-57-8
  • AHFC code:
  • Synonyms: Amlexanox [USAN:INN:JAN] Amlexanoxo [Spanish] Amlexanoxum [Latin]
  • ATC Code: A01AD07 R03DX01
  • Chemical Formula: C8H12N4O5
  • Molecular Weight: 298.2934
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB01025 (APRD00795)
  • SMILES: CC(C)C1=CC2=C(OC3=NC(N)=C(C=C3C2=O)C(O)=O)C=C1
  • InChl: SGRYPYWGNKJSDL-UHFFFAOYSA-N
  • PubChem: 2161
  • IUPAC: 2-amino-5-oxo-7-(propan-2-yl)-5H-chromeno[2,3-b]pyridine-3-carboxylic acid

Additional Details

Indication:
Used as a paste in the mouth to treat aphthous ulcers (canker sores).
Pharmacodynamics:
Amlexanox is a mucoadhesive oral paste which has been clinically proven to abort the onset, accelerate healing and resolve the pain of aphthous ulcers (canker sores). It decreases the time ulcers take to heal. Because amlexanox decreases the healing time, it also decreases the pain you feel. Recent studies have also shown that the majority of ulcers can be prevented by application of the paste during the prodromal (pre-ulcerative) phase of the disease. Recurrent Aphthous Ulcers (RAU) also known as Recurrent Aphthous Stomatitis (RAS) is recognized as the most common oral mucosal disease known to man. Estimates suggest that 20% – 25% of the general population suffer at least one incidence of aphthous ulcers each year. Amlexanox is also being investigated for its anti-allergenic and anti-inflammatory properties.
Mode of Action:
As a benzopyrano-bipyridine carboxylic acid derivative, amlexanox has anti-inflammatory and antiallergic properties. It inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3. When cells are under stress, they release an inactive form of human fibroblast growth factor 1 (FGF-1), a potent mitogen (entity that causes mitosis). Amlexanox binds to FGF1, increasing its conformational stability, sterically blocking Cu(2+) induced oxidation which normally leads to activation of FGF-1.
Metabolism:
Metabolized to hydroxylated and conjugated metabolites.
Toxicity:
General Reference:
Bell J: Amlexanox for the treatment of recurrent aphthous ulcers. Clin Drug Investig. 2005;25(9):555-66. Pubmed
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