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Acetazolamide

CAS No:
59-66-5 Categories: ,
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  • #LGM Pharma offers this active ingredient but not the finished dosage forms.

Product Details:

  • CAS No: 59-66-5
  • AHFC code: 52:10.0
  • Synonyms: Acetamidothiadiazolesulfonamide Acetazolamid Acetazolamide Sodium Acetazolamine Acetazoleamide Acetozalamide Carbonic Anhydrase Inhibitor 6063
  • ATC Code: S01EC01
  • Chemical Formula: C5H15N2O3PS
  • Molecular Weight: 222.245
  • Assay/Purity: Typically NLT 98%
  • DrugBank: DB00819 (APRD00119, EXPT00604)
  • SMILES: CC(=O)NC1=NN=C(S1)S(N)(=O)=O
  • InChl: BZKPWHYZMXOIDC-UHFFFAOYSA-N
  • PubChem: 1986
  • IUPAC: N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide

Additional Details

Indication:
For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma
Pharmacodynamics:
Acetazolamide is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion, in the treatment of certain convulsive disorders and in the promotion of diuresis in instances of abnormal fluid retention. Acetazolamide is not a mercurial diuretic. Rather, it is a nonbacteriostatic sulfonamide possessing a chemical structure and pharmacological activity distinctly different from the bacteriostatic sulfonamides.
Mode of Action:
The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.
Metabolism:
Toxicity:
General Reference:
Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1). Any patent infringement and resulting liability is solely at buyer risk.

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